Jauan Jennings faces a Week 2 decision as he battles a shoulder injury that kept him sidelined at times in Week 1. With Brock Purdy out, the 49ers could lean on the run game and Christian McCaffrey, while Mac Jones starts at quarterback for the injury-plagued SF squad. If Jennings suits up, he could oscillate between a low-end flex and a risky upside play against a Saints secondary that's not impenetrable. If he sits, Ricky Pearsall and McCaffrey become the more dependable options, with Marquez Valdez-Scantling as a speculative depth piece.

The absence of George Kittle opens volume for others, but the QB switch may cap overall passing upside. Jennings’ value hinges on health and the Saints’ true pass defense; in a game likely dominated by the run, even a limited Jennings can carve out a usable role, though major upside isn’t guaranteed. Fantasy managers should weigh Jennings’ injury status heavily against the Week 2 risk/reward of this matchup.

Mac Jones arrives in San Francisco with swagger that fits Shanahan’s offense, and the 49ers want to take over the Saints’ home field in Week 2. His locker-room energy and humor have teammates buying in as the offense seeks a steady, multi-faceted attack.

Demario Davis and New Orleans aim to slow Christian McCaffrey and pressure Jones, while San Francisco expects McCaffrey to anchor a heavy-volume game plan. Fantasy angles lean toward McCaffrey’s volume and Pearsall’s growing role, with a predicted low-scoring clash that tests both defenses and play-calling limits.